Quality control in microscope images (whether from whole slide scanners or traditional microscopes) is paramount to accurate analysis, especially across studies, imaging devices and repositories. Color correction (including methods such as color normalization, color standardization and color calibration) has been shown to accommodate for color batch effects, and is especially beneficial for automated analysis and computer-assisted diagnosis.
Most approaches to correcting color variation as a batch artifact are found only in the literature, but commercial solutions are now available, and can be adapted to qualify or even calibrate acquisition devices, as is the proposal by the FDA for digital pathology.
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